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Targeting TGF- signaling to alleviate obesity Despite significant advances in understanding the role of the TGF- pathway in obesity, obesity-induced diseases, and cancer, critical questions remain about whether this pathway functions predominantly as a driver or suppressor in these conditions

Watch for worsening pain and spreading redness beyond the immediate area after 48 to 72 hours, fever, a hard warm lump, or systemic allergic symptoms such as hives, facial swelling, throat tightness, or breathing difficulty

If it feels boring, the plan is working

Sanchez AM, Candau RB, Bernardi H

Key Takeaway: Titration is a safety-first approach designed to help your body build tolerance to semaglutide while minimizing gastrointestinal side effects